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pentobarbital will lessen the level or influence of pimozide by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Minor/Significance Unfamiliar.pentobarbital will minimize the extent or impact of siponimod by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Avoid or Use Alternate Drug. Coadministration of siponimod by using a drug that c